1. Restrepo, B.I., McEwen, J.G., Salazar, M.E. and A. Restrepo. (1986) Morphogenesis of the conidia produced by P. brasiliensis mycelial form. Journal of Medical and Veterinary Mycology. 24:337-339.
2. McEwen, J.G., Restrepo, B.I., Salazar, M.E. and A Restrepo. (1987) Nuclear staining of P. brasiliensis conidia.
3. Restrepo, B.I., Ahrens, J. and J.R. Graybill. (1989). Efficacy of SCH39304 in murine cryptococcosis. Antimicrobial Agents and Chemotherapy. 33:1242-1246.
4. Restrepo, B.I. and Barbour, A.G. (1989) Cloning of the 18S and 25S rDNAs from the pathogenic fungus Cryptococcus neoformans. Journal of Bacteriology. 171:5596-5600.
5. Burman, N., Bergstrom, S., Restrepo, B.I. and A.G. Barbour. (1990). The variable antigens Vmp7 and Vmp21 of the relapsing fever bacterium Borrelia hermsii are structurally analogous to the VSG proteins of the African trypanosome. Molecular Microbiology. 4:1715-1726.
6. Restrepo, B.I., Carter, C.J., Kitten, Infante, D. and A.G. Barbour. (1992). Subtelomeric expression regions of Borrelia hermsii linear plasmids are highly polymorphic. Molecular Microbiology. 6(22):3299-3311.
7. Wilske, B., Barbour, A.G., Bergstrom, S., Burman, N., Restrepo, B.I., Rosa, P.A., Schwan, T., Soutschek, E. and R. Wallich. (1992). Antigenic variation and strain heterogeneity in Borrelia spp. Research in Microbiology. 143:583-96.
8. Restrepo, B.I., Carter, C., and Barbour, A.G. (1994). Activation of a vmp pseudogene in Borrelia hermsii: an alternate mechanism of antigenic variation during relapsing fever. Molecular Microbiology. 13;287-299.
9. Restrepo, B.I. and Barbour, A.G. (1994). Antigen diversity in the bacterium B. Hermsii through "somatic" mutations in rearranged vmp genes. Cell. 78:867-876.
10. Hinnebusch, B.J., Barbour, A.G., Restrepo, B.I. and Schwan T.G. (1998). Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins. Infection and Immunity. 66:432-440.
11. Restrepo, B.I., Llaguno, P., Sandoval, M.A., Enciso, J.A. and Teale, J.M. (1998). Analysis of immune lesions in neurocysticercosis patients: Central nervous system response to helminth appears Th-1 instead of Th2. Journal of Neuroimmunology. 89:64-72.
12. Cardona, A.E., Restrepo, B.I., Jaramillo, J.M., Teale, J.M. (1999). Development of an animal model for neurocycticercosis: Immune response in the central nervous system is characterized by a predominance of T cells. Journal of Immunology. 161:995-1002.
13. Restrepo, B.I., Obregón-Henao, A., Mesa, M., Gil, D.L., Ortiz, B.L., Mejia, J.S., Villota, G.E., Sanzón, A.F., Teale, J.M. (2000). Characterization of the carbohydrate components of Taenia solium metacestode glycoprotein antigens. International Journal for Parasitology. 30:689-696.
14. Barbour, A.G., Restrepo, B.I. (2000). Antigenic variation in vector-borne pathogens: a common strategy. Emerging Infectious Diseases. 6:449-457.
15. Obregón-Henao, A., Gil, D.L., Sanzón, F., Gómez, D.I., Teale, J.M., Restrepo, B.I. (2001). The role of N-linked carbohydrates in the antigenicity of Taenia solium metacestode glycorproteins of 12, 16 and 18 kilodaltons. Molecular and Biochemical Parasitology. 114:209-215.
16. Restrepo, B.I., Alvarez, J. I., Castaño, J.A., Arias, L.F., Restrepo, M., Colegial, C., Teale, J.M. (2001). Brain granulomas in neurocysticercosis patients are associated with a Th1 and Th2 profile. Infection and Immunity. 69:4554-60.
17. Restrepo, B.I., Aguilar, M.I., Melby, P.C., Teale, J.M. (2001). Analysis of the peripheral immune response in patients with neurocysticercosis: Evidence for T cell reactivity to parasite glycoprotein and vesicular fluid antigens. American Journal of Tropical Medicine and Hygiene. 65:366-70.
18. Melby, P.C., Tabares, A., Restrepo, B.I., Cardona, A.E., McGuff, H.S., Teale, J.M. (2001). Leishmania donovani: Evolution and architecture of the splenic cellular immune response related to control of infection. Experimental Parasitology. 99:17-25.
19. Sanzón, F., Osorio, A.M., Morales, J.P., Isaza, R., Cardona, E., Moncayo, L.C., Villota, G.E., Holguín, J., Zapata, O.T., Palacio, C.A., Arbeláez, M.P., Gil, D.L., Gómez, D.I., Restrepo, B.I. (2002). Serology for neurocysticercosis in mentally-altered individuals. Tropical Medicine and International Health. 7:532-8.
20. Alvarez, J.I., Castaño, C.A., Colegial, C., Restrepo, M., Trujillo, J., Teale, J.M., Restrepo, B.I. (2002). The human nervous tissue in proximity to granulomatous lesions induced by Taenia solium metacestodes displays an active response. Journal of Neuroimmunology. 127; 139-144.
21. Alvarez, J.I., Londoño, D.P., Alvarez, A.L., Trujillo, J., Jaramillo, M.M., Restrepo, B.I. (2002). Granuloma formation and parasite disintegration in procine cysticercosis: Comparison to human neurocysticercosis. Journal of Comparative Pathology. 127:186-193.
22. Londoño, D.P., Alvarez, A.L., Trujillo, J., Jaramillo, M.M., Restrepo, B.I. (2002). The inflammatory cell infiltrates in porcine cysticercosis: Immunohistochemical analysis during various stages of infection. Veterinary Parasitology. 109:249-259.
23. Haslam, S.M., Restrepo, B.I., Obregón-Henao, A., Teale, J.M., Morris, H.R., Dell, A. (2002). Structural characterization of the N-linked glycans from Taenia solium metacestodes. Molecular and Biochemical Parasitology. 126:103-7.
24. Villota, G.E., Gomez, D.I., Volcy, M., Franco, A.F., Cardona, E.A., Isaza, R., Sanzón, F., Teale, J.M., Restrepo, B.I. (2003). Similar diagnostic performance for neurocysticercos using three glycoprotein preparations from Taenia solium metacestodes. American Journal for Tropical Medicine and Hygiene. 68:276-80.
25. Obregón-Henao, A., Londoño, D.P., Gómez, D.I., Trujillo, J., Teale, J.M., Restrepo, B.I. (2003). In situ detection of the antigenic glycoproteins and other glycoconjugates in Taenia solium metacestodes. Journal of Parasitology. 89:726-732.
26. Mirza, S., Restrepo, B.I., McCormick, J.B., Fisher-Hoch, S.P. (2003). Diagnosis of tuberculous lymphadenitis using a polymerase chain reaction on peripheral blood mononuclear cells. American Journal for Tropical Medicine and Hygiene. 69:461-5.
27. Restrepo, B.I. (2004). Nuevas herramientas para la detección de tuberculosis latente. BIOMÉDICA. 24(Supl):202-11 (invited review).
28. Pérez, A.P., Brown, H.S., Restrepo, B.I. The association between tuberculosis and diabetes in South Texas. American Journal for Tropical Medicine and Hygiene. in press

TITLE: CREATION OF AN HISPANIC HEALTH RESEARCH CENTER IN THE LOWER RIO GRANDE VALLEY.
Funding source: NIH- EXPORT; MD000170 020- National Center on Minority Health and Health Disparities (NCMHD). Total funding: $7,500,000/5 years. Start date: February 1, 2003. Principal Investigator: Dr. Joseph McCormick. Dr. Restrepo's roles of in the project: Contribution to design and writing of grant, and execution, analysis and publication of data.

1. Co-investigator of Molecular core: $625,825/5yrs; $92,167/yr one) 30% effort
1. Overall aim: Develop three Core Laboratories at the University of Texas School of Public Health at Brownsville to support the community health research programs proposed in the Export Grant. These include quantitative, real-time polymerase chain reaction, proteomics and microarrays.

TITLE: EMERGING MDR TUBERCULOSIS ACROSS THE US/MEXICO BORDER. Funding source: NIAID R21 A1056207. Start date: August 2003. Total funding: $400,000/2 years. Approved no cost extension for one more year. Dr. Restrepo's role in the project: Co-Principal Investigator and Project Coordinator 15% effort (PI is Dr. Joseph McCormick, UT-SPH-Brownsville).

TITLE: ENHANCED SURVEILLANCE TO IDENTIFY MISSED OPPORTUNITIES FOR PREVENTION OF TUBERCULOSIS IN FOREIGN-BORN. Funding source: Center for Disease control task Order 9#($30,822/2 years). Start date: June 2005. Dr. Restrepo's role in project: PI for UTHSC-Houston, School of Public Health 1% FTE (PI for Texas Consortium is Dr. Edward Gravis, Baylor College of Medicine, Houston).

TITLE: ALTERED IMMUNITY IN DIABETICS WITH TUBERCULOSIS. Funding source: PRIME Grant, School of Public Health, UTHSCH ($50,000/2 years). Start date: November 2004. Dr. Restrepo's role in project: PI.

TITLE: PATIENTS WITH T2DM HAVE INCREASED RISK OF MDR TUBERCULOSIS. University Clinical Research Center at Hermann Hospital. Total Funding: $11,965/1 yr. Start Date: October 2005. PI: Dr. Susan P. Fisher-Hoch. Dr. Restrepo's role in the project: Co-Investigator.

TITLE: RAPID CHARACTERIZATION OF MY COBACTERIA AND DRUG RESISTANCE IN PAUCIBACILLARY TB. NIAID. Total direct cost: $275,000/2 yr. Priority score: 140. Published final payline: 151. Start date: pending. Dr. Restrepo's role in the project: PI.

TITLE: CREATION OF AN HISPANIC HEALTH RESEARCH CENTER IN THE LOWER RIO GRANDE VALLEY
Funding source: NIH- EXPORT; MD000170 020- National Center on Minority Health and Health Disparities (NCMHD). Total Funding: $7,500,000/5 years. Start date: February 1, 2003. Principal Investigator: Dr. Joseph McCormick. Dr. Restrepo's roles of in the project: Contribution to design and writing of grant, and execution, analysis and publication of data

1. Principal Investigator of Pilot Study: ($55,000 direct costs/2 yrs) Early tuberculosis detection by high-throughput Q-PCR. 15% effort. HIH- EXPORT; MD000170 020
1. Overall aim: Design and validate a battery of real-time, quantitative PCR assays (Q-PCR) to study the dynamics of early Mycobacterium tuberculosis (MTB) infection, by detection of bacterial DNA in peripheral blood mononuclear cells (PBMCs).
2. Co-Investigator of Pilot study: Diabetes and tuberculosis: The strength of their association and the economic impact in the Lower Rio Grande Valley (LRGV). ($41,176 direct costs/1 year) 5% effort

• Overall aim: Based on the testing hypothesis that diabetes contributes to the burden of TB in the Hispanic population from four Texas counties along the Mexican-American border, in this study we will: i) determine the degree of association of DB and TB among Hispanics in the LRGV, ii) determine the strength of the association between TB and its associated risk factors, and iii) estimate health production function that will identify relevant socioeconomic indicators of TB and diabetes.